LAST FEBRUARY, Cathy Jones family gave her a special
Valentines Day gift: a tripaloneto Las Vegas. What
should have been a relaxing, solitary vacation was instead a scary nightmare,
at least while Jones was in the air.
On the plane to Las Vegas, she began to have trouble breathing.
She was lightheaded, dizzy and overwhelmed with fear. A panic attack.
Not her first, but they never get any easier.
I finally made it to Las Vegas, got off the plane,
and I was fine, Jones recalls. I didnt have any problems
while I was there. But when I went to the airport to check in and come
home, I couldnt get on the plane.
Finally, Jones forced herself, deciding that if she didnt,
she might never see her husband and son again. But she spent most of the
flight home in the planes bathroom, literally sick with worry. Not
all plane rides have had that effect on her. Nor have they been the only
trigger for her panic attacks. Jones never knew what would set off her
next attack.
Jones experience is typical for those with panic disorder,
a condition that occurs in 1.5 to 3.5 percent of the population. Some
people associate their panic attacks with particular events or circumstances
like flying in a plane. But they dont have to be associated with
anything, according to Keith E. Isenberg, MD, associate professor of psychiatry
at the School of Medicine.
The most important dimensions of panic disorder are
the rapid onset of symptoms, which are much more extensive than would
occur in common anxiety, say before giving a speech, he says. Another
important part of panic disorder is the anxiety that lingers between attacks.
That can be as disabling, or more disabling, than the attacks themselves.
Isenberg is principal investigator for the St. Louis site
of a multicenter study testing pregabalin, an investigational drug that
has shown early promise in treating panic disorder. Preliminary results
suggest the drug works quickly without many of the unpleasant side effects
that accompanied past drug therapies for panic disorder.
Years ago, researchers made the serendipitous observation
that drugs called tricyclic antidepressants not only eased depression,
but also helped to control panic attacks in depressed patients. From there,
it was a short step to determine that the drugs also helped to control
panic attacks in patients who were not depressed.
Since then, newer antidepressant drugs called Selective
Serotonin Reuptake Inhibitors (SSRIs) have been tested in patients with
panic attacks. Those drugs are somewhat effective, too. But Isenberg says
neither type of medication is ideal.
Antidepressants can take several weeks to work
sometimes even a month, or moreand they can cause unwanted side
effects in some patients, such as jitteriness, sexual dysfunction or gastrointestinal
problems, he says.
Benzodiazepines are another class of drugs that has proven
useful in panic attacks. These drugs are known to enhance the function
of a particular neurotransmitter in the brain called GABA (gamma-aminobutyric
acid). The GABA molecule is the brains major inhibitory neurotransmitter.
In the brain, benzodiazepines enhance the effectiveness
of GABA, particularly at type A GABA receptors on neurons. Clinically,
the drugs frequently provide almost instantaneous relief from panic attacks.
But some patients develop tolerance over time, and
the drugs are no longer effective, Isenberg says. Plus, benzodiazepines
can be associated with excessive sleepiness, clumsiness and memory problems.
Even so, the GABA connection was worth exploring further
because some anti-seizure medications work by enhancing GABA production.
Isenberg and other researchers have wondered whether panic attackswith
their heart palpitations, breathing difficulties and other physical symptomsmight
be some type of emotional or behavioral seizures. One drug
that has been tested is gabapentin.
There is some evidence that gabapentin, and other
drugs like it, enhance the amount of GABA available at the nerve terminals
where the neurotransmitter is released, Isenberg says.
In this study, Isenberg is investigating a related drug,
pregabalin. Like gabapentin, pregabalin is thought to increase the amount
of GABA available at receptor sites on neurons.
The theory is that releasing GABA at those specific
sites increases the inhibitory tone of the nervous system and, presumably
by that mechanismand this is not really clear, by the waydecreases
anxiety, Isenberg says.
Diagnosing the problem
Although she had suffered attacks off and on for more than
a decade, Cathy Jones wasnt aware she had panic disorder until after
her Las Vegas trip.
The Sunday after I returned, I saw an ad in the newspaper
and responded to it. I told them what my symptoms were, and they told
me to come in as quickly as possible, Jones recalls.
When she called the phone number in the ad, the voice on
the other end of the line belonged to Theresa Kormos, coordinator for
the pregabalin study.
Its not unusual for a person not to know whats
wrong or to think theyre the only one in the world who suffers from
these attacks, says Kormos. Many patients with panic disorderlike
those with other psychiatric illnessesnever get plugged into the
mental health system.
For 13 years, a parade of doctors had told Jones various
things about her attacks. One neurologist said she had a brain tumor,
another told her that when she was under stress, her brain stem rubbed
up against one of the bones in her spine, leading to the attacks.
People with panic disorder are frequently evaluated
by primary care physicians or by specialists because their physical symptoms
can be so striking, says Isenberg. Many receive cardiac stress
tests, tests of lung function or evaluations of their gastrointestinal
systems."
Although many doctors had evaluated Jones over the years,
none had figured out what was actually wrong or how to treat it. She had
undergone numerous tests, but when all was said and done, the consensus
was that she simply would have to live with her problems.
Panic disorder typically strikes people in their late teens
through 30s. During attacks, patients often report a racing heart, shortness
of breath, chest pain, upset stomach or some combination of those symptoms.
Attacks come suddenly, can become disabling in just a few
minutes and typically last for about an hour. Although many people have
attacks, only those who continue to experience anxiety between their attacks
are classified as having panic disorder.
Pregabalin therapy may alleviate the symptoms of this paralyzing
form of dread.
It seems to have done that for Cathy Jones. She was randomized
into the active arm of the study, and Kormos and Isenberg explained to
her that she might receive an inactive placebo. She quickly realized that
she had not.
I knew within three days, Jones recalls. My
body told me that it felt different. I just knew I wasnt on a sugar
pill.
Jones has since been part of the open-label group of patients.
After completing the initial 12-week study, she was offered an opportunity
to continue taking the study drug.
It was an easy decision, considering that she has not had
a panic attack since last winter. That followed six months in which the
attacks were coming almost daily.
A possible solution
Jones never sought the psychiatric help she needed because
she was secretly worried that she was crazy, and she thought a psychiatrist
might confirm that fear.
I would think, When will I have another attack?
What am I going to be doing when it happens? What if Im in a car?
What if I have my son with me? For me, the fear of having people
think I was crazy was as bad as the attacks themselves, she says.
Cathy is fairly typical of the patients we see,
says Kormos. She had been told so many things over the years, and
no one had been able to make the problem go away. Because so few of these
patients get proper treatment, after a while people like Cathy can begin
to think that they, themselves, are the problem.
Kormos and Isenberg are optimistic that pregabalin will
help people like Jones and that once the word is out, more people with
panic disorder will seek help.
No treatment is going to work for everybody all of
the time, Isenberg warns. We simply want something thats
very safe and can help some people with panic disorder. It appears possiblewe
have to wait for the results of the trialthat this medication may
offer those things.
*Cathy Jones is a pseudonym
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