Our center strives to offer the most successful
infertility care available, while remembering that this is a highly personal
issue to all our patients.
Randall R. Odem, MD
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SOMEHOW, KATHY KULIG
JUST KNEW that she would one day have a baby. Even a bout with breast
cancer at age 29 did not discourage her. Neither did four surgical procedures,
followed by a failed attempt at in vitro fertilization (IVF). Finally,
a second IVF try yielded two tiny embryos, which doctors implanted in her
uterus. Then Kathy and her husband, Matthew, sat back and held their breath.
The outcome of that attempt is visible throughout their
Millstadt IL home: in the diapers and baby carriers, in the changing table
and cheerful play area. Today, Kathy is the mother of picture-book twin
daughters, 11-month-old Kelly and Melaniea double miracle made possible
by Kathys persistence and the medical skill of the School of Medicines
Center for Infertility and Reproductive Medicine.
The center treats couples who are struggling with infertility
or recurrent miscarriage due to various underlying problems: polycystic
ovary syndrome, endometriosis, pelvic adhesions or tubal disease in women;
varicoceles, blocked vas deferens or low sperm count in men. To all of
them, the center offers the latest therapies, some still in clinical trial,
delivered with sensitivity to their emotional needs.
Playtime at home with twins Melanie, left, and Kelly,
and mom Kathy Kulig.
In this hectic time, it is rare for busy medical personnel
to sit down to listen and construct an individualized treatment plan.
Our center strives to offer the most successful infertility care available,
while remembering that this is a highly personal issue to all our patients,
says Randall R. Odem, MD, associate professor of obstetrics and gynecology
and director of the division of reproductive endocrinology and infertility.
In 1995, Kathy Kulig needed that kind of personal attention.
Diagnosed with early-stage breast cancer, she had just undergone surgery
at Barnes-Jewish Hospital when doctors discovered a pelvic problem. It
was not ovarian cancer as they had feared but a bad case of endometriosisabnormal
tissue growth in the pelvic areaa fertility-impairing condition
that would worsen as she took post-cancer hormone therapy.
In the midst of all this, Matt asked me to marry him,
says Kathy, who was then a school drug-prevention coordinator. We
knew we wanted children, and I even suggested forgoing the cancer treatment
so I could have them right awaybut I also wanted to be around to
raise them.
Referred to the center, she had a series of procedures to
remove the adhesions, but they always grew back. Before the third surgery,
her endometrial mass had grown to the size of a grapefruit. Then Valerie
S. Ratts, MD, assistant professor of obstetrics and gynecology and one
of four reproductive endocrinologists on staff, advised Kulig that IVFthe
retrieval of her eggs and their fertilization in the laboratory with her
husbands spermwas her best hope for achieving pregnancy.
IVF is a burgeoning area of therapy at the center. In the
mid-1990s, its physicians performed 100 to 120 retrievals a year; in 1999,
they did 292, plus 37 frozen embryo transfers. By the end of 2000, they
expect the years total to exceed 370.
Success rates have followed suit. In 1999, the center achieved
clinical pregnancy rates52 percent in women under 35, 27 percent
in the 35 to 39 age group, and 21 percent in women over 39that placed
them in the top group of U.S. fertility programs. In women over 45, the
center recommends the use of donor eggs for successful conception. The
centers oldest patient to date has been a 52-year-old woman who
just had her second child.
I can sum up the reason for our success in two words:
our lab," says Daniel B. Williams, MD, associate professor of obstetrics
and gynecology and director of the IVF program since 1995. The embryology
lab is the cornerstone of any IVF program, and ours is especially adept
at handling embryos and doing micro- manipulation procedures. We also
use blastocyst transferculturing embryos for five days instead of
the usual two or threeto observe them longer and select the hardiest
for implantation.
While the centers rates are impressive, a few infertility
centers publish statistics that look, on paper, even higher. But patients
may wish to take a closer look, cautions Williams. Some programs can potentially
increase success rates by screening out those who are not ideal candidateswhile
the center here treats even the most challenging patient cases.
Kulig, herself an avid Internet researcher, shopped around
and found two programs with sky-high IVF success rates. She even sent
her blood work to one, which quickly turned her down. The doctor
called and said, You cant come into our program and, quite
frankly, I dont think you will ever have children of your own,
she says.
So Kulig returned to the School of Medicine, where she had
her first in vitro cycle in July 1998. The treatment did not succeed:
She produced just two eggs, and only one achieved fertilization. She and
her husband decided to gamble and have the embryo implantedbut no
pregnancy resulted.
There are many reasons for IVF failure, including poor egg
quality. Severe sperm problems can sometimes be overcome through a procedure
called intracytoplasmic sperm injection (ICSI), in which doctors inject
the sperm into the egg and force fertilization to take place. But sometimes,
the reasons for the failure are mysterious.
We get eggs that look fine, we get sperm that looks
fine, we get fertilization and an embryo that begins to grow and looks
pretty good, Ratts says. Then we place it in the uterus and
it just doesnt take. Are there uterine or implantation factors at
work? Some of this is still unknown.
For couples undergoing IVF, the two-week waiting period
following implantation is filled with roller-coaster emotions. Will the
procedure work or will the womans menstrual period begin as usual,
signaling failure to conceive? Despite every medical effort, some couples
never achieve pregnancya devastating blow. The centers physicians
and its infertility counselor, Gail Gordon, work with these patients to
help them achieve closure.
In May 1999, the Kuligs decided to try again. While they
had paid out-of-pocket for the first cycle, their financial decision was
easier this time; their insurance company had agreed to provide partial
coverage, on the grounds that Kathys cancer therapy had impeded
her fertilityconstituting a disability under the Americans with
Disabilities Act. But there was still no shortage of anxiety.
On the day after Mothers Day, Ratts retrieved two
eggs from Kathy and sent them to the lab. Soon the fertilized cells were
dividing and the eggs looked strong, so the implantation procedure took
place; then the waiting period began. One night, discouraged, Kathy told
her husband that she thought the cycle had failed, but Matt, an optimist,
still held out hope. Kathy decided to take a home pregnancy test just
to show him. That test came back positive; the next day, a second did
too. So Kathy went in early for her blood test, which showed surprisingly
strong hormone levels. Do you think it could be twins? she
ventured. Two weeks later, ultrasound revealed two fuzzy forms growing
comfortably in her uterus. It was wonderful. We were so thrilled,
crying, she recalls, crying even now at the memory of it.
Twins and triplets are doable pregnancies, says
Ratts, but the center works hard to avoid multiple gestations by limiting
embryo placements to two for patients under age 33, three for those up
to age 39. For medical reasons, we dont want multiple gestations,
we want one good healthy baby, she says.
The Kuligs twin daughters were born on January 18,
2000, weighing 7 pounds and 6 pounds, 7 ounces, after an uncomplicated
pregnancy. Melanies middle name is Elizabeth for the
biblical figurelong past childbearing agewho gave birth to
John the Baptist. Now Kathy, more than five years free of cancer, is planning
a trip back to the center for another IVF cycleand just maybe another
child.
With luck, she will someday be showing off a third baby
in the center, where the staff loves to pose for pictures with the children
of grateful patients. Birth announcements and newborn photos also arrive
frequently by mail.
At the end of a hard day, it is wonderful to find
one of those little-bitty envelopes in the mail. You just know what is
in it, says Ratts. And you say to yourself: OK, today
was a hard day, but look what happened when I had a hard day nine months
agothis is the result.
The Center for Infertility and Reproductive Medicine
has an active egg donor program that is
currently seeking women ages 18 to 32 who are willing to donate eggs to
help infertile couples. A rigorous screening process is involved; donors
are compensated for their time. For more information, contact the center
at (314) 286-2419.
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