IN A HALF CENTURY, psychiatry went full circle from the stereotypical analyst’s couch to the lab, the pharmacy, the brain scanner and back to personalized therapies. The critical difference that emerged is that a discipline founded on intuition now relies on evidence-based methodologies. • Parts of this transformation begain in the Department of Psychiatry at Washington University School of Medicine. Iconoclasts here dared challenge the precepts of their profession. Their pioneering research still inspires successors to pursue similar goals in the understanding of psychiatric illness. • Demystifying Psychiatry, by Charles F. Zorumski, MD, and Eugene H. Rubin, MD, PhD, explains what trends in psychiatry have meant for patients and families.